Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model

Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical trials in glioblastoma (GBM) patients. Ultrasound-mediated blood–brain barrier opening (UMBO) using low-intensity pulsed ultrasound improved drug delivery to the brain. We explored the safety and the efficacy...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Mohammed H., Hernández-Verdin, Isaias, Quissac, Emie, Lemaire, Nolwenn, Guerin, Coralie, Guyonnet, Lea, Zahr, Noël, Mouton, Laura, Santin, Mathieu, Petiet, Alexandra, Schmitt, Charlotte, Bouchoux, Guillaume, Canney, Michael, Sanson, Marc, Verreault, Maïté, Carpentier, Alexandre, Idbaih, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967384/
https://www.ncbi.nlm.nih.gov/pubmed/36839777
http://dx.doi.org/10.3390/pharmaceutics15020455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967384/
https://www.ncbi.nlm.nih.gov/pubmed/36839777
http://dx.doi.org/10.3390/pharmaceutics15020455

Ejemplares similares