In Vitro/In Vivo Evaluation of Clomipramine Orodispersible Tablets for the Treatment of Depression and Obsessive-Compulsive Disorder

The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%. It is heavily protein-bound and broadly dispersed...

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Detalles Bibliográficos
Autores principales: Ghumman, Shazia Akram, Hameed, Huma, Noreen, Sobia, Al-Hussain, Sami A., Kausar, Rizwana, Irfan, Ali, Shabbir, Ramla, Rana, Maria, Amanat, Amina, Zaki, Magdi E. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967651/
https://www.ncbi.nlm.nih.gov/pubmed/37259410
http://dx.doi.org/10.3390/ph16020265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967651/
https://www.ncbi.nlm.nih.gov/pubmed/37259410
http://dx.doi.org/10.3390/ph16020265

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