Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites’ identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), followed by...

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Detalles Bibliográficos
Autores principales: Barcherini, Valentina, Loureiro, Joana B., Sena, Ana, Madeira, Catarina, Leandro, Paula, Saraiva, Lucília, Antunes, Alexandra M. M., Santos, Maria M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967700/
https://www.ncbi.nlm.nih.gov/pubmed/37259297
http://dx.doi.org/10.3390/ph16020146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967700/
https://www.ncbi.nlm.nih.gov/pubmed/37259297
http://dx.doi.org/10.3390/ph16020146

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