Preclinical Efficacy of a PARP-1 Targeted Auger-Emitting Radionuclide in Prostate Cancer

There is an unmet need for better therapeutic strategies for advanced prostate cancer. Poly (ADP-ribose) polymerase-1 (PARP-1) is a chromatin-binding DNA repair enzyme overexpressed in prostate cancer. This study evaluates whether PARP-1, on account of its proximity to the cell’s DNA, would be a goo...

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Detalles Bibliográficos
Autores principales: Sreekumar, Sreeja, Zhou, Dong, Mpoy, Cedric, Schenk, Elsa, Scott, Jalen, Arbeit, Jeffrey M., Xu, Jinbin, Rogers, Buck E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967758/
https://www.ncbi.nlm.nih.gov/pubmed/36834491
http://dx.doi.org/10.3390/ijms24043083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967758/
https://www.ncbi.nlm.nih.gov/pubmed/36834491
http://dx.doi.org/10.3390/ijms24043083

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