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Preclinical Efficacy of a PARP-1 Targeted Auger-Emitting Radionuclide in Prostate Cancer

There is an unmet need for better therapeutic strategies for advanced prostate cancer. Poly (ADP-ribose) polymerase-1 (PARP-1) is a chromatin-binding DNA repair enzyme overexpressed in prostate cancer. This study evaluates whether PARP-1, on account of its proximity to the cell’s DNA, would be a goo...

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Detalles Bibliográficos
Autores principales:	Sreekumar, Sreeja, Zhou, Dong, Mpoy, Cedric, Schenk, Elsa, Scott, Jalen, Arbeit, Jeffrey M., Xu, Jinbin, Rogers, Buck E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967758/ https://www.ncbi.nlm.nih.gov/pubmed/36834491 http://dx.doi.org/10.3390/ijms24043083

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