Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F(1)F(O)-ATPase and Mitochondrial Permeability Transition Pore Formation

An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Enaminones and nitrilimines generated in situ were se...

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Detalles Bibliográficos
Autores principales: Algieri, Vincenzo, Algieri, Cristina, Costanzo, Paola, Fiorani, Giulia, Jiritano, Antonio, Olivito, Fabrizio, Tallarida, Matteo Antonio, Trombetti, Fabiana, Maiuolo, Loredana, De Nino, Antonio, Nesci, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967880/
https://www.ncbi.nlm.nih.gov/pubmed/36839821
http://dx.doi.org/10.3390/pharmaceutics15020498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967880/
https://www.ncbi.nlm.nih.gov/pubmed/36839821
http://dx.doi.org/10.3390/pharmaceutics15020498

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