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Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F(1)F(O)-ATPase and Mitochondrial Permeability Transition Pore Formation

An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Enaminones and nitrilimines generated in situ were se...

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Detalles Bibliográficos
Autores principales:	Algieri, Vincenzo, Algieri, Cristina, Costanzo, Paola, Fiorani, Giulia, Jiritano, Antonio, Olivito, Fabrizio, Tallarida, Matteo Antonio, Trombetti, Fabiana, Maiuolo, Loredana, De Nino, Antonio, Nesci, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967880/ https://www.ncbi.nlm.nih.gov/pubmed/36839821 http://dx.doi.org/10.3390/pharmaceutics15020498

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