R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase cis-P3H-Mediated Selective Synthesis of (2S,3R)-3-Hydroxypipecolic Acid

Pipecolic acid (Pip) and its derivative hydroxypipecolic acids, such as (2S,3R)-3-hydroxypipecolic acid (cis-3-L-HyPip), are components of many natural and synthetic bioactive molecules. Fe(II)/α-ketoglutaric acid (Fe(II)/2-OG)-dependent dioxygenases can catalyze the hydroxylation of pipecolic acid....

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Detalles Bibliográficos
Autores principales: Guan, Jiaojiao, Lu, Yilei, Dai, Zixuan, Zhao, Songyin, Xu, Yan, Nie, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968057/
https://www.ncbi.nlm.nih.gov/pubmed/36838840
http://dx.doi.org/10.3390/molecules28041854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968057/
https://www.ncbi.nlm.nih.gov/pubmed/36838840
http://dx.doi.org/10.3390/molecules28041854

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