Cargando…

Design, Synthesis, and Biological Evaluation of a Small-Molecule PET Agent for Imaging PD-L1 Expression

Immunotherapy blocking programmed cell death protein 1/programmed death ligand 1 (PD-1/PD-L1) pathway has achieved great therapeutic effect in the clinic, but the overall response rate is not satisfactory. Early studies showed that response to treatment and overall survival could be positively relat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Liang, Zhang, Lixia, Liang, Beibei, Zhu, Shiyu, Lv, Gaochao, Qiu, Ling, Lin, Jianguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968138/ https://www.ncbi.nlm.nih.gov/pubmed/37259361 http://dx.doi.org/10.3390/ph16020213

Ejemplares similares

Development of a radiolabeled site-specific single-domain antibody positron emission tomography probe for monitoring PD-L1 expression in cancer
por: Chen, Yinfei, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
por: Pla-López, Alberto, et al.
Publicado: (2022)

Drug Design, Synthesis and Biological Evaluation of Heterocyclic Molecules as Anti-Inflammatory Agents
por: Savjani, Jignasa, et al.
Publicado: (2022)

A fluorine-18 labeled radiotracer for PET imaging of γ-glutamyltranspeptidase in living subjects
por: Gao, Dingyao, et al.
Publicado: (2021)

Design and Biological Evaluation of Small-Molecule PET-Tracers for Imaging of Programmed Death Ligand 1
por: Krutzek, Fabian, et al.
Publicado: (2023)

Preparation and Biological Evaluation of Two Novel Platinum(II) Complexes Based on the Ligands of Dipicolyamine Bisphosphonate Esters
por: Qiu, Ling, et al.
Publicado: (2016)

Design and Synthesis of Organic Molecules as Antineoplastic Agents
por: Boga, Carla, et al.
Publicado: (2020)

One-Step (18)F-Labeling of Estradiol Derivative for PET Imaging of Breast Cancer
por: Huang, Hongbo, et al.
Publicado: (2018)

Artificial Small Molecules as Cofactors and Biomacromolecular Building Blocks in Synthetic Biology: Design, Synthesis, Applications, and Challenges
por: Liu, Fenghua, et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Novel Thienylpyridyl- and Thioether-Containing Acetamides and Their Derivatives as Pesticidal Agents
por: Li, Huan, et al.
Publicado: (2021)

Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
por: Liang, Meihao, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists
por: Butera, Roberto, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel (99m)Tc-Labelled Bisphosphonates as Superior Bone Imaging Agents
por: Qiu, Ling, et al.
Publicado: (2011)

Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
por: Łupicka-Słowik, Agnieszka, et al.
Publicado: (2020)

Applications of Cryo-EM in small molecule and biologics drug design
por: Lees, Joshua A., et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Biphenylglyoxamide-Based Small Molecular Antimicrobial Peptide Mimics as Antibacterial Agents
por: Yu, Tsz Tin, et al.
Publicado: (2020)

Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis
por: Qiu, Ling, et al.
Publicado: (2019)

Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme
por: Sharma, Dolly, et al.
Publicado: (2023)

Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor
por: Girdhar, Khyati, et al.
Publicado: (2022)

Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
por: Li, Dingzhong, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Multi-Target Anti-Cancer Agent PYR26
por: He, Sirong, et al.
Publicado: (2023)

Development of a Promising (18)F-Radiotracer for PET Imaging Legumain Activity In Vivo
por: Lu, Chunmei, et al.
Publicado: (2022)

Fourteen small molecule and biological agents for psoriatic arthritis: A network meta-analysis of randomized controlled trials
por: Qiu, Mingliang, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Pyrimidine-oxazolidin-2-arylimino Hybrid Molecules as Antibacterial Agents
por: Romeo, Roberto, et al.
Publicado: (2018)

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
por: Ghasemi, Saeed, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Ciprofloxacin- Peptide Conjugates as Anticancer Agents
por: Esfandiari Mazandaran, Kiana, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
por: Madia, Valentina Noemi, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation of morpholinopyrimidine derivatives as anti-inflammatory agents
por: Fatima, Sadaf, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of N′-Phenylhydrazides as Potential Antifungal Agents
por: Zhu, Panpan, et al.
Publicado: (2023)

Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents
por: Wang, Chao, et al.
Publicado: (2013)

Small molecules and conjugates as theranostic agents
por: Pratihar, Sumon, et al.
Publicado: (2023)

Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer
por: Gao, Jian, et al.
Publicado: (2016)

Approaching the Dimerization Mechanism of Small Molecule Inhibitors Targeting PD-L1 with Molecular Simulation
por: Liang, Jianhuai, et al.
Publicado: (2023)

Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells
por: Brickute, Diana, et al.
Publicado: (2022)

Small-Molecule Poly(ADP-ribose) Polymerase and PD-L1 Inhibitor Conjugates as Dual-Action Anticancer Agents
por: Ofori, Samuel, et al.
Publicado: (2019)

Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors
por: Dong, Haiyang, et al.
Publicado: (2023)

A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes
por: Lee, Chia-Chung, et al.
Publicado: (2016)

Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents
por: Chen, Xiaofei, et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
por: Zheng, Shilong, et al.
Publicado: (2014)

Design, Synthesis, and Biological Evaluation of Axitinib Derivatives
por: Wei, Na, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_36vdf1enaak5l4b35d638jru37