Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats

Poor and variable oral bioavailability of furosemide (FUR) presents critical challenges in pharmacotherapy. We investigated the interplay of breast cancer resistance protein (Bcrp)-mediated transport, sex, and fed state on FUR pharmacokinetics (PK) in rats. A crossover PK study of FUR (5 mg/kg, oral...

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Detalles Bibliográficos
Autores principales: Sharma, Sheena, Mettu, Vijaya Saradhi, Prasad, Bhagwat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968170/
https://www.ncbi.nlm.nih.gov/pubmed/36839862
http://dx.doi.org/10.3390/pharmaceutics15020542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968170/
https://www.ncbi.nlm.nih.gov/pubmed/36839862
http://dx.doi.org/10.3390/pharmaceutics15020542

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