Single-cell quantification and dose-response of cytosolic siRNA delivery

Endosomal escape and subsequent cytosolic delivery of small interfering RNA (siRNA) therapeutics is believed to be highly inefficient. Since it has not been possible to quantify cytosolic amounts of delivered siRNA at therapeutic doses, determining delivery bottlenecks and total efficiency has been...

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Detalles Bibliográficos
Autores principales: Hedlund, Hampus, Du Rietz, Hampus, Johansson, Johanna M., Eriksson, Hanna C., Zedan, Wahed, Huang, Linfeng, Wallin, Jonas, Wittrup, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968291/
https://www.ncbi.nlm.nih.gov/pubmed/36841822
http://dx.doi.org/10.1038/s41467-023-36752-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968291/
https://www.ncbi.nlm.nih.gov/pubmed/36841822
http://dx.doi.org/10.1038/s41467-023-36752-1

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