Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells

Bioactive small-molecule inhibitors represent a treasure chest for future drugs. In vitro high-throughput screening is a common approach to identify the small-molecule inhibitors that bind tightly to purified targets. Here, we investigate the inhibitor-target binding/unbinding kinetics in E. coli ce...

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Detalles Bibliográficos
Autores principales: Le, Dai, Akiyama, Tatsuya, Weiss, David, Kim, Minsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968327/
https://www.ncbi.nlm.nih.gov/pubmed/36841892
http://dx.doi.org/10.1038/s42003-023-04604-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968327/
https://www.ncbi.nlm.nih.gov/pubmed/36841892
http://dx.doi.org/10.1038/s42003-023-04604-9

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