Cargando…
Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells
Bioactive small-molecule inhibitors represent a treasure chest for future drugs. In vitro high-throughput screening is a common approach to identify the small-molecule inhibitors that bind tightly to purified targets. Here, we investigate the inhibitor-target binding/unbinding kinetics in E. coli ce...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968327/ https://www.ncbi.nlm.nih.gov/pubmed/36841892 http://dx.doi.org/10.1038/s42003-023-04604-9 |