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Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S

Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein. We then describe steps to determine the outcome of immunization by challenging immunized mice with a lethal dose of MERS...

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Detalles Bibliográficos
Autores principales: Zheng, Jian, Channappanavar, Rudra, Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968614/
https://www.ncbi.nlm.nih.gov/pubmed/36920912
http://dx.doi.org/10.1016/j.xpro.2023.102171