Optimization of 5′UTR to evade SARS-CoV-2 Nonstructural protein 1-directed inhibition of protein synthesis in cells

ABSTRACT: Maximizing the expression level of therapeutic proteins in cells is the general goal for DNA/mRNA therapies. It is particularly challenging to achieve efficient protein expression in the cellular contexts with inhibited translation machineries, such as in the presence of cellular Nonstruct...

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Detalles Bibliográficos
Autores principales: Chen, Shih-Cheng, Xu, Cui-Ting, Chang, Chuan-Fu, Chao, Ting-Yu, Lin, Chia-Chi, Fu, Pei-Wen, Yu, Chien-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Applied Genetics and Molecular Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968647/
https://www.ncbi.nlm.nih.gov/pubmed/36843199
http://dx.doi.org/10.1007/s00253-023-12442-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968647/
https://www.ncbi.nlm.nih.gov/pubmed/36843199
http://dx.doi.org/10.1007/s00253-023-12442-2

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