Plasma biomarkers TAP, CPA1, and CPA2 for the detection of pancreatic injury in rat: the development of a novel multiplex IA-LC-MS/MS assay and biomarker performance evaluation

Drug-induced pancreatic injury (DIPI) is an issue seen in drug development both in nonclinical and clinical contexts. DIPI is typically monitored by measurement of lipase and/or amylase, however, both enzymes lack sensitivity and specificity. Although candidate protein biomarkers specific to pancrea...

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Detalles Bibliográficos
Autores principales: Vlasakova, Katerina, Steinhilber, Andreas, Bailey, Wendy J., Erdos, Zoltan, Haag, Hanna, Joos, Thomas, Ackermann, Bradley L., Poetz, Oliver, Glaab, Warren E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968696/
https://www.ncbi.nlm.nih.gov/pubmed/36481916
http://dx.doi.org/10.1007/s00204-022-03425-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968696/
https://www.ncbi.nlm.nih.gov/pubmed/36481916
http://dx.doi.org/10.1007/s00204-022-03425-9

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