Positive allosteric GABA(A) receptor modulation counteracts lipotoxicity-induced gene expression changes in hepatocytes in vitro

Introduction: We have previously shown that the novel positive allosteric modulator of the GABA(A) receptor, HK4, exerts hepatoprotective effects against lipotoxicity-induced apoptosis, DNA damage, inflammation and ER stress in vitro. This might be mediated by downregulated phosphorylation of the tr...

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Detalles Bibliográficos
Autores principales: Rohbeck, Elisabeth, Niersmann, Corinna, Köhrer, Karl, Wachtmeister, Thorsten, Roden, Michael, Eckel, Jürgen, Romacho, Tania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968943/
https://www.ncbi.nlm.nih.gov/pubmed/36860523
http://dx.doi.org/10.3389/fphys.2023.1106075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968943/
https://www.ncbi.nlm.nih.gov/pubmed/36860523
http://dx.doi.org/10.3389/fphys.2023.1106075

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