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Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies
Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for treating solid tumors. However, genetic engineering and scalable production of somatic macrophages remains significant challenges. Here, we used CRISPR-Cas9 gene editing methods to integrate an anti-GD2 CAR into...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968983/ https://www.ncbi.nlm.nih.gov/pubmed/36638788 http://dx.doi.org/10.1016/j.stemcr.2022.12.012 |