Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with increased numbers of X-linked escape genes and sex-biased gene expression

Sex differences exist for many lung pathologies, including COVID-19 and pulmonary fibrosis, but the mechanistic basis for this remains unclear. Alveolar type 2 cells (AT2s), which play a key role in alveolar lung regeneration, express the X-linked Ace2 gene that has roles in lung repair and SARS-CoV...

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Detalles Bibliográficos
Autores principales: Sierra, Isabel, Pyfrom, Sarah, Weiner, Aaron, Zhao, Gan, Driscoll, Amanda, Yu, Xiang, Gregory, Brian D., Vaughan, Andrew E., Anguera, Montserrat C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968984/
https://www.ncbi.nlm.nih.gov/pubmed/36638790
http://dx.doi.org/10.1016/j.stemcr.2022.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968984/
https://www.ncbi.nlm.nih.gov/pubmed/36638790
http://dx.doi.org/10.1016/j.stemcr.2022.12.005

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