A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1. Patients with MFS notably suffer from aortic aneurysm and dissection. Despite considerable effort, animal models have proven to be poorly predictive for therapeutic intervention in human aortic disease. Patient-d...

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Detalles Bibliográficos
Autores principales: Davaapil, Hongorzul, McNamara, Madeline, Granata, Alessandra, Macrae, Robyn G.C., Hirano, Mei, Fitzek, Martina, Aragon-Martin, J.A., Child, Anne, Smith, David M., Sinha, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968988/
https://www.ncbi.nlm.nih.gov/pubmed/36669494
http://dx.doi.org/10.1016/j.stemcr.2022.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968988/
https://www.ncbi.nlm.nih.gov/pubmed/36669494
http://dx.doi.org/10.1016/j.stemcr.2022.12.014

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