Generation of functional human T cell development in NOD/SCID/IL2rγ(null) humanized mice without using fetal tissue: Application as a model of HIV infection and persistence

Humanization of mice with functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic tissue (so-called BLT mouse model). Here, we show that NOD/SCID/IL2rγ(null) mice humanized with cord blood- derived CD34(+) cells and implanted wi...

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Detalles Bibliográficos
Autores principales: Colas, Chloé, Volodina, Olga, Béland, Kathie, Pham, Tram N.Q., Li, Yuanyi, Dallaire, Frédéric, Soulard, Clara, Lemieux, William, Colamartino, Aurélien B.L., Tremblay-Laganière, Camille, Dicaire, Renée, Guimond, Jean, Vobecky, Suzanne, Poirier, Nancy, Patey, Natasha, Cohen, Éric A., Haddad, Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969074/
https://www.ncbi.nlm.nih.gov/pubmed/36736326
http://dx.doi.org/10.1016/j.stemcr.2023.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969074/
https://www.ncbi.nlm.nih.gov/pubmed/36736326
http://dx.doi.org/10.1016/j.stemcr.2023.01.003

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