An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway

BACKGROUND: Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to antibody-mediated autoimmune diseases, while impaired differentiation results in immunodeficiency. METHODS: We have used CRISPR/Cas9 te...

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Detalles Bibliográficos
Autores principales: Trezise, Stephanie, Kong, Isabella Y., Hawkins, Edwin D., Herold, Marco J., Willis, Simon N., Nutt, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969136/
https://www.ncbi.nlm.nih.gov/pubmed/36860866
http://dx.doi.org/10.3389/fimmu.2023.1089243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969136/
https://www.ncbi.nlm.nih.gov/pubmed/36860866
http://dx.doi.org/10.3389/fimmu.2023.1089243

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