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An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway

BACKGROUND: Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to antibody-mediated autoimmune diseases, while impaired differentiation results in immunodeficiency. METHODS: We have used CRISPR/Cas9 te...

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Detalles Bibliográficos
Autores principales:	Trezise, Stephanie, Kong, Isabella Y., Hawkins, Edwin D., Herold, Marco J., Willis, Simon N., Nutt, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969136/ https://www.ncbi.nlm.nih.gov/pubmed/36860866 http://dx.doi.org/10.3389/fimmu.2023.1089243

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