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Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines

Plasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozoite invasion of erythrocytes by Plasmodium spp. Ou...

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Detalles Bibliográficos
Autores principales: Drew, Damien R., Wilson, Danny W., Weiss, Gretchen E., Yeoh, Lee M., G. Henshall, Isabelle, Crabb, Brendan S., Dutta, Sheetij, Gilson, Paul R., Beeson, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969379/
https://www.ncbi.nlm.nih.gov/pubmed/36847896
http://dx.doi.org/10.1007/s00018-023-04712-z