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Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads

[Image: see text] Interest in covalent enzyme inhibitors as therapeutic agents has seen a recent resurgence. Covalent enzyme inhibitors typically possess an organic functional group that reacts with a key feature of the target enzyme, often a nucleophilic cysteine residue. Herein, the application of...

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Detalles Bibliográficos
Autores principales: Karges, Johannes, Cohen, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969397/
https://www.ncbi.nlm.nih.gov/pubmed/36752718
http://dx.doi.org/10.1021/acs.jmedchem.2c02074