A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases

[Image: see text] The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 loss/dysfunction triggers a cascade of neurodegenerative events, comprising glutamatergic excitotoxicit...

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Detalles Bibliográficos
Autores principales: Fontana, Igor C., Souza, Débora G., Souza, Diogo O., Gee, Antony, Zimmer, Eduardo R., Bongarzone, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969404/
https://www.ncbi.nlm.nih.gov/pubmed/36787643
http://dx.doi.org/10.1021/acs.jmedchem.2c01572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969404/
https://www.ncbi.nlm.nih.gov/pubmed/36787643
http://dx.doi.org/10.1021/acs.jmedchem.2c01572

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