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A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases
[Image: see text] The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 loss/dysfunction triggers a cascade of neurodegenerative events, comprising glutamatergic excitotoxicit...
Autores principales: | Fontana, Igor C., Souza, Débora G., Souza, Diogo O., Gee, Antony, Zimmer, Eduardo R., Bongarzone, Salvatore |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969404/ https://www.ncbi.nlm.nih.gov/pubmed/36787643 http://dx.doi.org/10.1021/acs.jmedchem.2c01572 |
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