Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes

[Image: see text] Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-bonding capacity. However, these properties impact also their passive membrane permeability. As the “journey” through membranes cannot be monitored experimentally, little is known about t...

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Detalles Bibliográficos
Autores principales: Linker, Stephanie M., Schellhaas, Christian, Kamenik, Anna S., Veldhuizen, Mac M., Waibl, Franz, Roth, Hans-Jörg, Fouché, Marianne, Rodde, Stephane, Riniker, Sereina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969412/
https://www.ncbi.nlm.nih.gov/pubmed/36762908
http://dx.doi.org/10.1021/acs.jmedchem.2c01837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969412/
https://www.ncbi.nlm.nih.gov/pubmed/36762908
http://dx.doi.org/10.1021/acs.jmedchem.2c01837

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