Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain

BACKGROUND: The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be suitable antigens for T-cell therapy of MM. METHODS: Using immunopeptidomics, we identified Jchain-derived epitopes presented by...

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Detalles Bibliográficos
Autores principales: Meeuwsen, Miranda H., Wouters, Anne K., Wachsmann, Tassilo L. A., Hagedoorn, Renate S., Kester, Michel G. D., Remst, Dennis F. G., van der Steen, Dirk M., de Ru, Arnoud H., van Hees, Els P., Kremer, Martijn, Griffioen, Marieke, van Veelen, Peter A., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969645/
https://www.ncbi.nlm.nih.gov/pubmed/36850001
http://dx.doi.org/10.1186/s13045-023-01408-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969645/
https://www.ncbi.nlm.nih.gov/pubmed/36850001
http://dx.doi.org/10.1186/s13045-023-01408-6

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