Synthetic cytokine circuits that drive T cell infiltration into immune-excluded tumors

CAR T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the inflammatory cytokine, interleukin-2 (IL-2). These cytokine delivery circuits can pot...

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Detalles Bibliográficos
Autores principales: Allen, Greg M., Frankel, Nicholas W., Reddy, Nishith R., Bhargava, Hersh K., Yoshida, Maia A., Stark, Sierra R., Purl, Megan, Lee, Jungmin, Yee, Jacqueline L., Yu, Wei, Li, Aileen W., Garcia, K. Christopher, El-Samad, Hana, Roybal, Kole T., Spitzer, Matthew H., Lim, Wendell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970000/
https://www.ncbi.nlm.nih.gov/pubmed/36520915
http://dx.doi.org/10.1126/science.aba1624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970000/
https://www.ncbi.nlm.nih.gov/pubmed/36520915
http://dx.doi.org/10.1126/science.aba1624

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