Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice

In Alzheimer’s disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in ce...

Descripción completa

Detalles Bibliográficos
Autores principales: de Sousa, Diana M. Bessa, Benedetti, Ariane, Altendorfer, Barbara, Mrowetz, Heike, Unger, Michael S., Schallmoser, Katharina, Aigner, Ludwig, Kniewallner, Kathrin Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970308/
https://www.ncbi.nlm.nih.gov/pubmed/36734880
http://dx.doi.org/10.18632/aging.204502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970308/
https://www.ncbi.nlm.nih.gov/pubmed/36734880
http://dx.doi.org/10.18632/aging.204502

Ejemplares similares