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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Analysis of mutational signatures can reveal underlying molecular mechanisms of the processes that have imprinted the somatic mutations found in cancer genomes. Here, we analyze single base substitutions and small insertions and deletions in pediatric cancers encompassing 785 whole-genome sequenced...
Autores principales: | Thatikonda, Venu, Islam, S. M. Ashiqul, Autry, Robert J., Jones, Barbara C., Gröbner, Susanne N., Warsow, Gregor, Hutter, Barbara, Huebschmann, Daniel, Fröhling, Stefan, Kool, Marcel, Blattner-Johnson, Mirjam, Jones, David T. W., Alexandrov, Ludmil B., Pfister, Stefan M., Jäger, Natalie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970869/ https://www.ncbi.nlm.nih.gov/pubmed/36702933 http://dx.doi.org/10.1038/s43018-022-00509-4 |
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