Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

BACKGROUND & AIMS: Oxidative stress is recognized as a major driver of non-alcoholic steatohepatitis (NASH) progression. The transcription factor NRF2 and its negative regulator KEAP1 are master regulators of redox, metabolic and protein homeostasis, as well as detoxification, and thus appear to...

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Detalles Bibliográficos
Autores principales: Seedorf, Klaus, Weber, Csaba, Vinson, Cedric, Berger, Sylvie, Vuillard, Laurent-Michel, Kiss, Arpad, Creusot, Stephanie, Broux, Olivier, Geant, Anne, Ilic, Catherine, Lemaitre, Karine, Richard, Johann, Hammoutene, Adel, Mahieux, Julien, Martiny, Virginie, Durand, Didier, Melchiore, Fabien, Nyerges, Miklos, Paradis, Valerie, Provost, Nicolas, Duvivier, Valérie, Delerive, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971056/
https://www.ncbi.nlm.nih.gov/pubmed/36866391
http://dx.doi.org/10.1016/j.jhepr.2022.100651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971056/
https://www.ncbi.nlm.nih.gov/pubmed/36866391
http://dx.doi.org/10.1016/j.jhepr.2022.100651

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