Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

BACKGROUND & AIMS: Oxidative stress is recognized as a major driver of non-alcoholic steatohepatitis (NASH) progression. The transcription factor NRF2 and its negative regulator KEAP1 are master regulators of redox, metabolic and protein homeostasis, as well as detoxification, and thus appear to...

Descripción completa

Detalles Bibliográficos
Autores principales: Seedorf, Klaus, Weber, Csaba, Vinson, Cedric, Berger, Sylvie, Vuillard, Laurent-Michel, Kiss, Arpad, Creusot, Stephanie, Broux, Olivier, Geant, Anne, Ilic, Catherine, Lemaitre, Karine, Richard, Johann, Hammoutene, Adel, Mahieux, Julien, Martiny, Virginie, Durand, Didier, Melchiore, Fabien, Nyerges, Miklos, Paradis, Valerie, Provost, Nicolas, Duvivier, Valérie, Delerive, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971056/
https://www.ncbi.nlm.nih.gov/pubmed/36866391
http://dx.doi.org/10.1016/j.jhepr.2022.100651

Ejemplares similares

Ejemplares similares