The SWIB/MDM2 motif of UBE4B activates the p53 pathway

The tumor suppressor p53 plays a critical role in cancer pathogenesis, and regulation of p53 expression is essential for maintaining normal cell growth. UBE4B is an E3/E4 ubiquitin ligase involved in a negative-feedback loop with p53. UBE4B is required for Hdm2-mediated p53 polyubiquitination and de...

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Detalles Bibliográficos
Autores principales: Wu, H. Helena, Leng, Sarah, Abuetabh, Yasser, Sergi, Consolato, Eisenstat, David D., Leng, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971181/
https://www.ncbi.nlm.nih.gov/pubmed/36865087
http://dx.doi.org/10.1016/j.omtn.2023.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971181/
https://www.ncbi.nlm.nih.gov/pubmed/36865087
http://dx.doi.org/10.1016/j.omtn.2023.02.002

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