mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs

Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in liver tumorigenesis. However, the role of metabolic reprogramming in TICs remains poorly explored. Here, we identif...

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Detalles Bibliográficos
Autores principales: Chen, Zhenzhen, He, Qiankun, Lu, Tiankun, Wu, Jiayi, Shi, Gaoli, He, Luyun, Zong, Hong, Liu, Benyu, Zhu, Pingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971191/
https://www.ncbi.nlm.nih.gov/pubmed/36849569
http://dx.doi.org/10.1038/s41467-023-36651-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971191/
https://www.ncbi.nlm.nih.gov/pubmed/36849569
http://dx.doi.org/10.1038/s41467-023-36651-5

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