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Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology

Background: Several clinical trials have demonstrated that glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) reduce the incidence of non-fatal myocardial infarction (MI) in patients with type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains unclear. In this study, we...

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Detalles Bibliográficos
Autores principales: Deng, Guorong, Ren, Jiajia, Li, Ruohan, Li, Minjie, Jin, Xuting, Li, Jiamei, Liu, Jueheng, Gao, Ya, Zhang, Jingjing, Wang, Xiaochuang, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971732/
https://www.ncbi.nlm.nih.gov/pubmed/36865917
http://dx.doi.org/10.3389/fphar.2023.1125753