The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

INTODUCTION: Two scaffold/matrix attachment regions (5’- and 3’-MARs(Eµ) ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARs(Eµ) is still unclear and their involvement in somatic hyp...

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Detalles Bibliográficos
Autores principales: Martin, Ophélie A., Thomas, Morgane, Marquet, Marie, Bruzeau, Charlotte, Garot, Armand, Brousse, Mylène, Bender, Sébastien, Carrion, Claire, Choi, Jee Eun, Vuong, Bao Q., Gearhart, Patricia J., Maul, Robert W., Le Noir, Sandrine, Pinaud, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971809/
https://www.ncbi.nlm.nih.gov/pubmed/36865553
http://dx.doi.org/10.3389/fimmu.2023.1030813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971809/
https://www.ncbi.nlm.nih.gov/pubmed/36865553
http://dx.doi.org/10.3389/fimmu.2023.1030813

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