Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A

Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly simplifies any genetic engineering manipulations. Such antibodies have the ability to bind hard-to-reach antigenic epitopes through long part...

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Detalles Bibliográficos
Autores principales: Panova, Eugenia A., Kleymenov, Denis A., Shcheblyakov, Dmitry V., Bykonia, Evgeniia N., Mazunina, Elena P., Dzharullaeva, Alina S., Zolotar, Anastasia N., Derkaev, Artem A., Esmagambetov, Ilias B., Sorokin, Ivan I., Usachev, Evgeny V., Noskov, Anatoly N., Ivanov, Igor A., Zatsepin, Timofei S., Dmitriev, Sergey E., Gushchin, Vladimir A., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971915/
https://www.ncbi.nlm.nih.gov/pubmed/36865543
http://dx.doi.org/10.3389/fimmu.2023.1098302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971915/
https://www.ncbi.nlm.nih.gov/pubmed/36865543
http://dx.doi.org/10.3389/fimmu.2023.1098302

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