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White matter hyperintensities in cholinergic pathways are associated with dementia severity in e4 carriers but not in non-carriers
BACKGROUND AND OBJECTIVES: Among individuals with Alzheimer's disease (AD), APOE e4 carriers with increased white matter hyperintensities (WMHs) may selectively be at increased risk of cognitive impairment. Given that the cholinergic system plays a crucial role in cognitive impairment, this stu...
Autores principales: | Yu, Ming-Chun, Chuang, Yi-Fang, Wu, Shu-Ching, Ho, Cheng-Feng, Liu, Yi-Chien, Chou, Chia-Ju |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971995/ https://www.ncbi.nlm.nih.gov/pubmed/36864910 http://dx.doi.org/10.3389/fneur.2023.1100322 |
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