Cargando…

Immunogenicity of small‐cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition

INTRODUCTION: The activation of STING (stimulator of interferon genes) pathway enhances antitumor immunity in small‐cell lung cancer (SCLC), while the DNA damage induced by non‐cGAMP‐based agonists is a potent inducer of STING activity. Here, we investigate the intrinsic expression of STING in cance...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xuetao, Li, Yujun, Zhao, Ziwen, Miao, Nabo, Liu, Guorong, Deng, Liaoyuan, Wei, Shuquan, Hou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972012/
https://www.ncbi.nlm.nih.gov/pubmed/35957613
http://dx.doi.org/10.1002/cam4.5109