Cargando…

Immunogenicity of small‐cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition

INTRODUCTION: The activation of STING (stimulator of interferon genes) pathway enhances antitumor immunity in small‐cell lung cancer (SCLC), while the DNA damage induced by non‐cGAMP‐based agonists is a potent inducer of STING activity. Here, we investigate the intrinsic expression of STING in cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xuetao, Li, Yujun, Zhao, Ziwen, Miao, Nabo, Liu, Guorong, Deng, Liaoyuan, Wei, Shuquan, Hou, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972012/ https://www.ncbi.nlm.nih.gov/pubmed/35957613 http://dx.doi.org/10.1002/cam4.5109

Ejemplares similares

Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific
por: Li, Xuetao, et al.
Publicado: (2023)

Genomic features of Chinese small cell lung cancer
por: Liu, Jun, et al.
Publicado: (2022)

ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
por: Schultz, Christopher W, et al.
Publicado: (2023)

Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer
por: Liu, Chaofan, et al.
Publicado: (2023)

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer
por: Yoshida, Ryohei, et al.
Publicado: (2022)

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism
por: Bowler, Elizabeth, et al.
Publicado: (2020)

STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines
por: Padron-Regalado, Eriko, et al.
Publicado: (2022)

Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
por: Heath, Blake R., et al.
Publicado: (2023)

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer
por: Liu, Kang, et al.
Publicado: (2021)

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
por: Choi, Jun-Hyuk, et al.
Publicado: (2009)

The lncRNA HOTAIR regulates autophagy and affects lipopolysaccharide‐induced acute lung injury through the miR‐17‐5p/ATG2/ATG7/ATG16 axis
por: Li, Yujun, et al.
Publicado: (2021)

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma
por: Beumer, Jan H., et al.
Publicado: (2015)

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis
por: Wei, Shuquan, et al.
Publicado: (2019)

SLFN11 biomarker status predicts response to lurbinectedin as a single agent and in combination with ATR inhibition in small cell lung cancer
por: Kundu, Kiran, et al.
Publicado: (2021)

In vitro synergistic effect of amlodipine and imipenem on the expression of the AdeABC efflux pump in multidrug-resistant Acinetobacter baumannii
por: Hu, Chao, et al.
Publicado: (2018)

Molecular Characteristics and Quantitative Proteomic Analysis of Klebsiella pneumoniae Strains with Carbapenem and Colistin Resistance
por: Hao, Ling, et al.
Publicado: (2022)

(−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer
por: Yang, Xiaohui, et al.
Publicado: (2022)

Loss of STING expression is prognostic in non–small cell lung cancer
por: Lohinai, Zoltan, et al.
Publicado: (2022)

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence
por: Zhou, Zhong-Wei, et al.
Publicado: (2013)

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
por: Menolfi, Demis, et al.
Publicado: (2018)

ATR activation is regulated by dimerization of ATR activating proteins
por: Thada, Vaughn, et al.
Publicado: (2021)

TAI-SARNET: Deep Transferred Atrous-Inception CNN for Small Samples SAR ATR
por: Ying, Zilu, et al.
Publicado: (2020)

STING Targeting in Lung Diseases
por: de Moura Rodrigues, Dorian, et al.
Publicado: (2022)

Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
por: Eek Mariampillai, Adrian, et al.
Publicado: (2023)

The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
por: Sokka, Miiko, et al.
Publicado: (2018)

Discovery of Novel STING Inhibitors Based on the Structure of the Mouse STING Agonist DMXAA
por: Chang, Jiajia, et al.
Publicado: (2023)

A consensus set of genetic vulnerabilities to ATR inhibition
por: Hustedt, Nicole, et al.
Publicado: (2019)

Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency
por: Borror, Megan B., et al.
Publicado: (2022)

Diagnosis of Lung Cancer by ATR-FTIR Spectroscopy and Chemometrics
por: Yang, Xien, et al.
Publicado: (2021)

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma
por: Bommareddy, Praveen K., et al.
Publicado: (2019)

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma
por: Wang-Bishop, Lihong, et al.
Publicado: (2020)

A Germline Mutation in ATR Is Associated With Lung Adenocarcinoma in Asian Patients
por: Bao, Guangyao, et al.
Publicado: (2022)

The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response
por: Wang, Lili, et al.
Publicado: (2021)

Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
por: Yang, Chunsheng, et al.
Publicado: (2023)

Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway
por: Zhang, Jing, et al.
Publicado: (2023)

Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production
por: Qi, Shishi, et al.
Publicado: (2022)

Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer
por: Doerr, Fabian, et al.
Publicado: (2017)

Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR
por: Chien, Wenwen, et al.
Publicado: (2023)

Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway
por: He, Yu-Qiong, et al.
Publicado: (2021)

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine
por: Fang, Chunju, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1ted8f6conh3le15cnl011i60q