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Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1

Human RNA binding protein Musashi-1 (MSI1) plays a critical role in neural progenitor cells (NPCs) by binding to various host RNA transcripts. The canonical MSI1 binding site (MBS), A/GU((1-3))AG single-strand motif, is present in many RNA virus genomes, but only Zika virus (ZIKV) genome has been de...

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Detalles Bibliográficos
Autores principales: Chen, Xiang, Wang, Yan, Xu, Zhonghe, Cheng, Meng-Li, Ma, Qing-Qing, Li, Rui-Ting, Wang, Zheng-Jian, Zhao, Hui, Zuo, Xiaobing, Li, Xiao-Feng, Fang, Xianyang, Qin, Cheng-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972320/
https://www.ncbi.nlm.nih.gov/pubmed/36854751
http://dx.doi.org/10.1038/s41467-023-36838-w