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Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances

B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated a...

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Detalles Bibliográficos
Autores principales: Abdollahi, Nika, Jeusset, Lucile, de Septenville, Anne, Davi, Frederic, Bernardes, Juliana Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972711/
https://www.ncbi.nlm.nih.gov/pubmed/36849917
http://dx.doi.org/10.1186/s12859-022-05112-z