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Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances

B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated a...

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Detalles Bibliográficos
Autores principales:	Abdollahi, Nika, Jeusset, Lucile, de Septenville, Anne, Davi, Frederic, Bernardes, Juliana Silva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972711/ https://www.ncbi.nlm.nih.gov/pubmed/36849917 http://dx.doi.org/10.1186/s12859-022-05112-z

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