Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

BACKGROUND: More effective targeted therapy and new combination regimens are needed for Acute myeloid leukemia (AML), owing to the unsatisfactory long-term prognosis of the disease. Here, we investigated the synergistic effect and the mechanism of a histone deacetylase inhibitor, Chidamide in combin...

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Detalles Bibliográficos
Autores principales: Gu, Siyu, Hou, Yue, Dovat, Katarina, Dovat, Sinisa, Song, Chunhua, Ge, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972767/
https://www.ncbi.nlm.nih.gov/pubmed/36849955
http://dx.doi.org/10.1186/s40164-023-00383-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972767/
https://www.ncbi.nlm.nih.gov/pubmed/36849955
http://dx.doi.org/10.1186/s40164-023-00383-5

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