Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming toxin, streptolysin O (SLO). In this study, we utilized a r...

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Detalles Bibliográficos
Autores principales: Langshaw, Emma L., Reynolds, Simone, Ozberk, Victoria, Dooley, Jessica, Calcutt, Ainslie, Zaman, Mehfuz, Walker, Mark J., Batzloff, Michael R., Davies, Mark R., Good, Michael F., Pandey, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972915/
https://www.ncbi.nlm.nih.gov/pubmed/36744883
http://dx.doi.org/10.1128/mbio.03488-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972915/
https://www.ncbi.nlm.nih.gov/pubmed/36744883
http://dx.doi.org/10.1128/mbio.03488-22

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