HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein

Gelsolin (GSN) is a structural actin-binding protein that is known to affect actin dynamics in the cell. Using mass spectrometry, we identified GSN as a novel Vpr-interacting protein. Endogenous GSN protein was expressed at detectable levels in monocyte-derived macrophages (MDM) and in THP-1 cells,...

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Detalles Bibliográficos
Autores principales: Fabryova, Helena, Kao, Sandra, Sukegawa, Sayaka, Miyagi, Eri, Taylor, Louis, Ferhadian, Damien, Saito, Hideki, Schaal, Heiner, Hillebrand, Frank, Strebel, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972982/
https://www.ncbi.nlm.nih.gov/pubmed/36602307
http://dx.doi.org/10.1128/mbio.02973-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972982/
https://www.ncbi.nlm.nih.gov/pubmed/36602307
http://dx.doi.org/10.1128/mbio.02973-22

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