The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALLINIs, namely, BI-D and the drug candidate Pirmitegravir. Th...

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Detalles Bibliográficos
Autores principales: Singer, Matthew R., Dinh, Tung, Levintov, Lev, Annamalai, Arun S., Rey, Juan S., Briganti, Lorenzo, Cook, Nicola J., Pye, Valerie E., Taylor, Ian A., Kim, Kyungjin, Engelman, Alan N., Kim, Baek, Perilla, Juan R., Kvaratskhelia, Mamuka, Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973045/
https://www.ncbi.nlm.nih.gov/pubmed/36744954
http://dx.doi.org/10.1128/mbio.03560-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973045/
https://www.ncbi.nlm.nih.gov/pubmed/36744954
http://dx.doi.org/10.1128/mbio.03560-22

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