AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4

Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions when incorporated. In Jurkat Tag T lymphoid ce...

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Detalles Bibliográficos
Autores principales: Olety, Balaji, Usami, Yoshiko, Wu, Yuanfei, Peters, Paul, Göttlinger, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973267/
https://www.ncbi.nlm.nih.gov/pubmed/36622146
http://dx.doi.org/10.1128/mbio.03382-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973267/
https://www.ncbi.nlm.nih.gov/pubmed/36622146
http://dx.doi.org/10.1128/mbio.03382-22

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